"Tranquilizers as depicted in fiction are extremely unrealistic because as any anesthesiologist knows, determining the exact amount of drug needed for the patient (or here the target) is an exact science. The amount of drug used for a child would simply render an adult drowsy or have no effect, while the stuff you use to knock out an elephant would be fatal to the people you see here. It also doesn't take effect instantly like Snake is able to do, so the sentry you just shot in the neck would end up shooting at you and alerting the camp for a few minutes before finally dropping.

The best possible use I can see for tranquilizer dart guns is an emergency weapon, as an overdose of the drug can kill and a needle in the face is certainly debilitating to your fighting ability."

"Having been raised in a vet tech's home, there are some fast acting animal tranquilizers that will drop the target in a few seconds. The problem with these are that they are so potent, if you come in contact with them as they can be absorbed through the skin, it's fatal."

"Having been raised in a vet tech's home, there are some fast acting animal tranquilizers that will drop the target in a few seconds. The problem with these are that they are so potent, if you come in contact with them as they can be absorbed through the skin, it's fatal."

"That's a given Chit. I was more so trying to point out that filling darts and syringes with tranqs that powerful is also hazardous to whoever is using them. "

"Definately, they even had an umbrella version at one point. But I think the CIA has things and weapons we don't have a single idea about like the tranq gun. I mean they developed an aerosol spray that if touched would cause close to instant death."

"No I think it was an MI6 weapon supposed to be used against a KGB agent using ricin, but they also had one filled with an anesthetic that was measured out for another suspected KGB agent."

"I can't speak to the medical side of things, because I'm no doc, but it would seem to me, if we were talking the 28D/W Later zombies, then the issue might be their metabolism. As fast as they can move, it's possible that their functions have sped up, and therefore might very well metabolize (process and remove) the anesthetic, extremely quickly, so that if it didn't actually kill them, they might not stop, or, potentially worse, go down just long enough to lull you into a false sense of security, and then suddenly snap back to 'consciousness.'"